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This finding has direct implications for research protocol design: most published and structured study designs incorporate a rest period following the active phase to allow receptor sensitivity to normalize before any subsequent research cycle, rather than using continuous, uninterrupted administration

Chojnacki, C., Popawski, T., Konrad, P., Fila, M., Chojnacki, J., & Basiak, J

when the tumor progresses to the advanced stage, ROS exceeds the critical value, promoting DNA double-strand breaks and the 8-oxodG formation and leading to apoptosis

Grade II-IV acute-GVHD was observed in 14% of patients, 1-year chronic-GVHD cumulative incidence(CI) was 7%