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During all next steps purification steps the fractions were tested by restraint stress and cysteamine methods on experimental animals (Wistar rats)

Srebp-1, a basic-helixloophelix-leucine zipper protein that controls transcription of the low-density-lipoprotein receptor gene

10.1016/j.virol.2022.01.008 Virology 185 RothenD.DuttaS.KrengerP.PardiniA.VogtA.JosiR.et al

The selectivity of the peptide is further discussed by the researchers, who suggest that senescent cells may depend more strongly on FOXO4-mediated control of p53 localization and activity, so disrupting that node might preferentially remove cells that are already operating close to an apoptotic threshold