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It was first used in 2020 for diabetic foot ulcers via a clinical trial

27 Adverse effects reported in 1% or more of patients 12 years of age and older with seasonal allergic rhinitis who received extended-release tablets of cetirizine hydrochloride in fixed combination with pseudoephedrine hydrochloride (Zyrtec-D) included insomnia, dry mouth, fatigue, somnolence, pharyngitis, epistaxis, accidental injury, dizziness, and sinusitis

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Kubota M, Kobayashi N, Sugizaki T, Shimoda M, Kawahara M, Tanaka KI (2020) Carnosine suppresses neuronal cell death and inflammation induced by 6-hydroxydopamine in an in vitro model of Parkinsons disease