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In the early stages of the disease, pancreatic -cells are overworked in an attempt to regulate glucose levels, leading to cellular stress and eventual dysfunction [149]

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Similar combinations for example, SLC7A11-low neuroblastoma with LRP8 KO have previously been associated with partial ferroptosis rescue in vivo 25 , underscoring the complexity of this combinatorial cell death modality and highlighting the need for further mechanistic dissection