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This is manifested clinically by the skin becoming flaky, inelastic, and prone to recurrent infections and also to fluid loss through the skin, which in turn leads to polydipsia (Wallach & Hoff, 1982)

Saccular stage hyperoxia injury not only decreased the expression of the alveolar formation genes FOXM1, MYB and MCM2 but also overactivated Wnt/-catenin signalling