melanotic.macule Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome Pigmented lesions of the oral

Nature 583 , 290295 (2020)

Mast cell activation syndrome (MCAS) flares up when mast cells, which are located throughout the body, inappropriately release excessive amounts of chemical mediators, such as histamine, in response to a trigger, including one or more of the following: Alcohol An allergen Certain chemicals Certain food items (which vary among individuals) Certain fragrances (such as perfume or cologne) Certain medications Exposure to sunlight Heat or cold Heavy metals Infection (bacterial, viral, or fungal) Mold/fungus When mast cells function as they should, they help defend the body against threats, such as harmful viruses, bacteria, and fungi

Each vial contains 50mg of GHK-Cu also known as Copper Tripeptide-1 one of the most extensively studied copper peptides in published research

Their chemogenetic ablation led to the impairment of the vascular matrix, disrupted blood flow and worsened motor recovery 51