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doi: 10.1016/j.molmed.2017.06.005 13 CabuGCrianTOKlckVPoppRAJoostenLAB

The integration of these molecular mechanisms, orchestrated by AMPK, underscores metformins comprehensive therapeutic benefits beyond glycemic control, encompassing anti-inflammatory, antioxidant, and cytoprotective effects (Figure 1)

7 Limitations and Potential Risks Despite promising results, certain limitations and risks must be considered: Limited Sample Sizes and Durations: Many clinical studies on AOD 9604 have relatively small sample sizes and short durations, which may affect the generalizability of their findings