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Consequently, HIF-1 has been shown to upregulate NQO1 expression in response to stressful events, such as hypoxia

The skin then produces excess melanin in those areas as part of the healing process, resulting in dark spots known as post-inflammatory hyperpigmentation

Thus, oxidative damage in depression and anxiety disorders can aect the amygdala and hippocampus (Salim, 2017), among other brain structures, reduce neurogenesis (Hassan et al., 2014;van Velzen et al., 2017), and contribute to cognitive dysfunction (Duy et al., 2014)

By blocking ME2 to lower NADPH levels and adding BSO (GSH synthesis inhibitor) to enhance the ROS effect in concert, the oxidative defense barrier of AML cells was successfully broken (113, 157)