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This work has clinical relevance as MaT and MiT variants of NC-HCC may respond better to tyrosine kinase inhibitors and immunotherapy respectively

Key Takeaways CJC-1295 is a GHRH analogue that elevates baseline growth hormone levels over extended periods Ipamorelin is a selective GHRP that triggers acute, pulsatile GH release with minimal side effects Together, they create a synergistic effect that mimics the body's natural GH secretion rhythm CJC-1295 with DAC has a ~68 day half-life

However, there is a need for rigorous patient selection and close follow-up, as AHSCT involves significant risk, including treatment-related mortality (estimated at about 0.2% in the most recent data) and the development of secondary autoimmune disease

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