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He also holds appointments in the Departments of Pediatrics, Medicine and Molecular and Human Genetics at Baylor

10.1371/journal.pone.0132484 74 HollenbergN

Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors

Specifically, the protein ankyrin repeat and SOCS box protein 1 (ASB1) (a substrate-recognition subunit of an E3 ubiquitin ligase complex) binds to SQOR and mediates K48-linked ubiquitination of SQOR, targeting it for proteasomal degradation