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Nat Rev Gastroenterol Hepatol 2021;18:770-786

PGC-1 PGC1 binds to CCAAT/enhancer binding protein (CEBPB) to enhance CPT1A transcription, resulting in activation of FAO through PGC1/CEBPB/CPT1A/FAO signaling axis, which can promote radiation resistance of nasopharyngeal carcinoma (NPC) ( MiRNA regulation of CPT1A MiR-33a/b Several genes involved in fatty acid metabolism including CPT1A, HADHB contain predicted binding sites for miR-33a/b ( MiR-124 Downregulation of CPT1A expression by miR-124, limiting the conversion of long-chain acyl-CoA moieties to long-chain acylcarnitine (Valentino et al., 2017)

Similarly, activated microglia contribute to oxidative stress by upregulating NADPH oxidase 2 (NOX2), which generates O , and inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO)

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