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Modeling vanishing white matter disease with patient-derived induced pluripotent stem cells reveals astrocytic dysfunction

Vassilaki et al., 2018

As part of their defense mechanism, they release inflammatory cytokines to recruit immune cells, aiming to restore homeostasis

155 Additionally, targeting bile acid metabolism, such as through bile acid sequestrants and farnesoid X receptor agonists, has shown promise in preclinical models by reducing bile acid accumulation and hepatotoxicity