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Efforts are being made to design endonucleases capable of precisely disrupting the genomic sequences involved in the erythroid-specific expression of -globin repressors, as a means of activating HbF, but this remains a difficult challenge [43]

Neuroendocrine and neuroimmune research together allow us to conclude that stress, understood as distress or toxic stress, through the systemic effects of cortisol and norepinephrine, is capable of altering brain activity, by means of various mechanisms, still to be fully discovered in their complexity, that seem to center on two fundamental pathways: alteration of the structure of brain areas and circuits, induction of neuroinflammation and oxidative stress

This way we try to fill lack of information about melatonin-regulated pathways involved in antioxidant strategy of plant defense