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Furthermore, HDL suppression of intracellular adhesion molecule-1 (ICAM-1) in endothelial cells was found to be mediated, in part, through the transfer of miR-223 to recipient cells (773)

However, while HLMs provide one of the most convenient ways to assess CYP-mediated metabolism they hardly predict in vivo metabolism of phase II metabolism other than glucuronidation, or the combination of both phase I and II metabolism ( To summarize, 2D cell models of cell lines are the easiest to handle and most reproducible models for in vitro toxico-metabolomic studies