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CYP51A1-mediated cholesterol metabolism affects the synthesis of sex hormones and glucocorticoids, which can lead to heart defects and skeletal abnormalities [83, 84]

The ablative mechanism, on the other hand, involves the destruction of adipocytes through a detergent substance, such as phosphatidylcholine and deoxycholate [23]

Thus, exogenous glutathione may improve vasorelaxation via activation of NO signaling pathway which is known to be impaired with aging

The expression levels of pro-inflammatory cytokines were also significantly reduced, and the results overall suggest that Grx1-regulated S-glutathionylation in macrophages plays a protective role in acute lung injury (Figure 2)