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In the case of water-soluble vitamins like B12, vitamin C, folic acid, and other B vitamins, some medically reviewed literature points to early morning as the optimal time to take them as they can be taken on an empty stomach, but more peer-reviewed research is needed to confirm this claim

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Many individuals schedule B12 shots periodically based on provider recommendations

Some users mention being able to increase workout intensity or volume because their muscles dont stay fatigued as long