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The study found that m5C methylation modification-related genes were significantly correlated with the incidence of osteoarthritis and rheumatoid arthritis, regarded as a new potential diagnostic biomarker [109]

S2CID 25040280

The reaction catalyzed by -ECS/GSH1 is considered the rate-controlling step of GSH synthesis, and the activity of this enzyme is regulated by cellular levels of cysteine and glutamic acid, and feedback inhibition by -EC and GSH ( Figure 1 GSH1 (EC 6.3.2.2) is exclusively present in plastids, while GSH2 (EC 6.3.2.2) has dual localization in plastids and the cytosol, both encoded by a single gene (Wachter et al., 2005)