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Obesity is a well-established risk factor for the varicose veins and is strongly associated with systemic inflammation, increased oxidative stress, and metabolic dysfunction [19]

Omeprazole's ability to inhibit acid production by the parietal cell is contributing to a large portion of its effect on protein-bound vitamin B12

Navas LE, Carnero A

Endothelial dysfunction Copper dyshomeostasis has been linked to atherosclerosis, with both an excess and deficiency of copper contributing to endothelial dysfunction, a critical early step in atherogenesis