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Safety and efficacy of anti-vascular endothelial growth factor therapies for neovascular age-related macular degeneration: a report by the American academy of ophthalmology

Phase I reactions (primarily oxidation, reduction, and hydrolysis) structurally modify the parent compound but frequently generate reactive intermediates that can be more cytotoxic than the original molecules

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Two key benefits associated with nano-scale dimensions are the vast surface area of nanomaterials (NMs) relative to their volume and their capacity to enter the cytoplasm (increased intracellular assimilation) (Ben Amor et al., 2022)