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Abstract The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc- is composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the primary functional component responsible for cystine uptake and glutathione biosynthesis

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Interestingly, PHGDH also affects tumor biology independently of its effects in serine metabolism, for example, directly interacting with the RNA-binding protein Poly(rC)-binding protein 2 (PCBP2), and inhibiting its proteasomal degradation

These results indicate that we have found an efficient GST inhibitor, the F2 peptide, which is more efficient than hematin (35.2% activity with CDNB as a substrate, 42.1% activity with DCNB as a substrate)