chac1 glutathione L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated degradation in hepatocellular carcinoma Glutathione (GSH) depletion by ChaC1
Glutathione (GSH) depletion by ChaC1 results in a more oxidizing Download Scientific Diagram Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element ScienceDirect Frontiers The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications Mammalian proapoptotic factor ChaC1 and its homologues function as glutamyl cyclotransferases acting specifically on glutathione EMBO Reports Springer Nature Link
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