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GPx3 activity in patients with submaximal baseline GPx3 levels (subgroup IV) Subgroup IV consisted of patients with GPx3 baseline activity below 250 U/l ( n = 32)

found that 45% of East Asians have a deficiency in ALDH2 enzymatic activity, leading to ALD and increasing the risk of hepatocellular carcinoma (HCC) (Wang et al., 2021)