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256 The two main strategies targeting Notch have been identified, including GSIs (-secretase inhibitors) that can block the active NCID release to reduce the levels of active Notch, and mAbs that can either inhibit ligation upon cell contact or prevent proteolytic cleavage via stabilizing the NRR-region

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Evaluation of variation in the performance of GFR slope as a surrogate end point for kidney failure in clinical trials that differ by severity of CKD