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Two Palestinian brothers were reported to have jaundice and diarrhoea that started soon after birth [6]

doi: 10.3892/ijmm.2014.1658 255

Furthermore, gene expression in the frontal cortex of cynomolgus macaques exposed to various Mn doses indicates that the amyloid- (A) precursor-like protein 1 (APLP1) of the amyloid precursor family was highly up-regulated, thereby linking Mn exposure to AD ( In contrast to Mn-induced Parkinsonism, the pathogenesis of HD, an autosomal dominant disorder characterized by the neurodegeneration of medium spiny neurons in the striatum, appears to involve a Mn transport deficiency (Kumar et al., 2015)