glutathione s transferase alpha s-transferase The role of glutathione-S-transferase in anti-cancer drug resistance The role of glutathione S-transferases – Different classes of glutathione S-transferase.

Salidroside, a natural phenylpropanoid glycoside isolated from Rhodiola rosea , has been shown to enhance mitochondrial complex I activity by upregulating and phosphorylating AMPK2, increasing cardiomyocyte tolerance to I/R injury and reducing ferroptosis

2022;375: eabm9609

This process triggers ferroptosis, synergizes with photothermal therapy (PTT) by downregulating key ferroptosis suppressors GPX4 and FSP1, induces mitochondrial damage, and ultimately achieves complete tumor ablation

Similarly, treatment of cell culture models of intestinal epithelial layers (HT-29, T84, Caco-2) with estrogen receptor antagonists increases permeability while estrogen treatment prevents this outcome [89, 92]