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For people who really want to understand what B12 deficiencies can do, I recommend the book Could it be B12

See What are the possible side effects of fondaparinux sodium injection? had a serious allergic reaction to fondaparinux sodium injection Before using fondaparinux sodium injection, tell your doctor about all of your medical conditions, including if you: have had any bleeding problems (such as stomach ulcers) have had a stroke have had recent surgeries, including eye surgery have diabetic eye disease have kidney or liver problems have uncontrolled high blood pressure are pregnant or plan to become pregnant

296,298 One case report described the benefit of SAMe in a 32 year old patient with anxiety who was found to have a MTHFR gene mutation: treatment with methylated B 12 and folate was not effective for relieving symptoms until SAMe, 400 mg twice daily, was added

For safety reasons, always follow the directions on the supplement label