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These factors can help accelerate and strengthen tissue repair, and these further activate recruitment, integration, and differentiation of MSCs as well as expression of several tissue remodeling genes [3-7]

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It can also reduce the production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-, interleukin (IL)-1, and IL-6 ( 2 O 2 , which is mediated by downregulation of vascular cell adhesion molecule 1 and CD80 ( The excellent anti-oxidant activity of quercetin is mainly exerted via effects on the activity of glutathione, enzymes, and reactive oxygen species (ROS), and regulating signal transduction pathways such as heme oxygenase 1/nuclear factor erythroid 2-related factor (Nrf2), mitogen-activated protein kinase, toll-like receptor 4/phosphatidylinositol-3-kinase, and 5 adenosine monophosphate-activated protein kinase (32)

Other unusual features seen in functional blepharospasm, include the presence of unusual visual symptoms and the sudden onset of prolonged spasms, whereas in other forms of blepharospasm, there is increased eyeblink rate slowly evolving into more prolonged spasms (126)