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While there is no scientific evidence recommending against taking B12 at night, because of its role in energy production, it can elicit a stimulatory effect in some people, as do the other B vitamins

doi: 10.4103/1008-682x.182817 66 ChenFZhangHWangZDingWZengQLiuWet al

Growth hormone secretagogues produce full-spectrum growth hormone effects including potential appetite stimulation, IGF-1 elevation, and systemic metabolic changes affecting multiple tissues