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Dosimetry, a major issue Different ways to express doses and different dose ranges used When considering the studies dealing with the toxicity of e-cigarettes assessment, in addition to the heterogeneity of e-cigarette products, biological models, or exposure conditions observed, there is also a huge disparity in the doses used as well as in the way they are expressed as shown in Table 2

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This includes $29.5 billion in direct healthcare expenditures, $8.0 billion in indirect costs from illness, and $12.4 billion in indirect costs from death (American Lung Association [ALA], 2013b)