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doi: 10.1038/s41390-023-02747-3 195 ArjomandnejadMKopecALKeelerAM

Inhibition of Sirt2 by AGK2 restricted both drug-sensitive and drug-resistant M.tb strains, enhanced the efficacy of isoniazid, reduced the bacillary burden and improved disease pathology in M.tb -infected mice [141]

As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19