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Cancer-associated fibroblasts Cancer-associated fibroblasts (CAFs) stand out as one of the most abundant cell types in the CCA TME, and they have a role in cholangiocarcinogenesis 82,83

However, glutamine is a major driver for OXPHOS in cancer cells, and glutamine limitation, rather than glucose contributes to lower oxygen uptake and mediates the apoptosis of cancer cells ( The rate-limiting mitochondrial enzyme in glutamine metabolism is glutaminase, which catalyzes the conversion of glutamine into glutamate and ammonia

Qi J, Zhang L, Tan F, Zhang Y, Zhou Y, Zhang Z, Wang H, Yu C, Jiang L, Liu J, Chen T, Wu L, Zhang S, Sun S, Sun S, Lu L, Wang Q, Chai R

Carnilean combines targeted ingredients selected to support how the body converts fat into usable energy