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Kim T-H, Kim D-H, Lee SG

Moreover, IGF1R activated by IGF-1 plays a role in epidermal growth factor receptor (EGFR)-mediated primary or secondary resistance to colorectal cancer by upregulating the PI3K/AKT signaling pathway (16)

Two main hypotheses can be raised to explain lower efficacy of second-line medications [5]: either therapeutic failure is predominantly a marker of severity regardless of the sequence or the use of the first-line biologic is dramatically changing the immune system response [23] limiting the efficacy of a second therapy meaning that therapeutic sequencing is crucial and highly condition the long-term outcomes of patients with UC

10.1016/j.bbamem.2006.09.002 89 PalmadaM.SpeilA.JeyarajS.BhmerC.LangF