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Furthermore, target individual cytokines (anti-IL-1 glucocorticoids, anti-IL-6 simvastatin/haritaki) and small molecules that modulate upstream regulators such as p53 (nutlin-3a) or inhibit LINE-1-driven inflammatory signaling (nucleoside reverse transcriptase inhibitors like lamivudine) also function as SASP inhibitors

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Neurological changes A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as: vision problems memory loss pins and needles loss of physical co-ordination (ataxia), which can affect your whole body and cause difficulty speaking or walking damage to parts of the nervous system (peripheral neuropathy), particularly in the legs If neurological problems do develop, they can sometimes be irreversible