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5 Stem cells in intervertebral disc repair The most important pathological features of IVDD include metabolic imbalance of proteoglycans and type II collagen in the extracellular matrix (ECM), and a reduction in the number of nucleus pulposus cells (NPCs) (Xin et al., 2022)

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1,2 Each of these definitions carries a different meaning, and what the half-life of a drug is found to be can also vary or appear to vary depending on contexts such as formulation, route of administration, and individual variations in drug distribution, metabolism, and excretion, among other factors

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