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Future research should further validate the specificity and sensitivity of TfR1 as an early diagnostic marker and develop cost-effective detection technologies

In addition, TGF- can also facilitate fibrosis through multiple non-Smad-dependent pathways, such as those involving c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK1/2), and phosphatidylinositol 3-kinase/Akt (PI3K/Akt) or Rho-like GTPases (30, 40)

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Hoque TS, Hossain MA, Mostofa MG, Burritt DJ, Fujita M, Tran LSP (2016) Methylglyoxal: an emerging signaling molecule in plant abiotic stress responses and tolerance