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Oral tablets do not require the use of needles are typically taken daily can result in side effects such as nausea, vomiting, constipation, and abdominal pain must be taken on an empty stomach first thing in the morning, without eating for 30 minutes afterward Injections require the use of needles are typically taken once per week may cause side effects such as injection site reactions but may also cause nausea, vomiting, constipation, and abdominal pain can be taken regardless of whether you consume food or liquid beforehand or afterward You can inject semaglutide into your upper arm, thigh, or stomach