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As far as the clock-controlled expression of inflammatory mediators, BMAL1 has been demonstrated to generate basal oscillations in the expression of chemokines, such as CCL2, via interaction with the Polycomb repressor complex 2 (PRC2) in myeloid cells 55

While these studies may be interesting to elucidate the mechanisms of fluoride neurotoxicity, they have important limitations regarding the translational point of view based on the dose and temporal exposure window