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For humans, these interventions include supplementation with branched-chain amino acids such as leucine, isoleucine, and valine, beta-hydroxy-beta-methylbutyrate, carnitine, and creatine (162)

Two main groups of pLGG in vivo models have been generated by several labs with varying degree of success: patient-derived xenograft models of mostly non-NF1-pLGGs (60, 65, 66, 116) and genetically engineered mouse models mostly for NF1-pLGGs especially NF1-OPGs (70, 72, 7679, 82)

[DOI] [PubMed] [Google Scholar] 381.Oh SY, et al

Magn Reson Imaging 60:3237 Acknowledgements Professor Pravat K Mandal (Principal Investigator) thanks Indo-Australia strategic funding (BT/Indo-Aus/10/31/2016/PKM) and dementia science program (Principal investigator and Co-coordinator (PKM), Department of Biotechnology, Govt of India)