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found that indole-3-propionic acid (IPA) could reduce the gap in gut microbiota diversity between CCl4-induced mice and healthy counterparts, activated HSCs and the TGF-1/Smads signaling pathway, leading to hepatocyte apoptosis, increased expression of extracellular matrix components such as collagen I and -SMA, ultimately promoting liver fibrosis (Liu et al., 2021)

Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test

In 3rd step (buffer stage II), which comprised a simulation of large intestinal fluid, the pH of the dissolution medium was further raised up to pH = 7.3 by the addition of 100 mL of 0.3 M sodium hydroxide (NaOH) or 87 mL of 0.05 M Na 3 PO 4 12 H 2 O for further 3.5 h of dissolution testing

J Hum Hypertens 33 , 725734 (2019)