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Simvastatin combined with resistance training improves outcomes in patients with chronic heart failure by modulating mitochondrial membrane potential and the Janus Kinase/Signal transducer and activator of Transcription 3 signaling pathways

Abstract Alcoholic brain damage (ABD) stems from chronic excessive alcohol consumption, causing neuroinflammation, oxidative stress, mitochondrial dysfunction, and neuronal apoptosis, all of which severely impair cognition and quality of life

Methotrexate exacerbates NAFLD by inhibiting antioxidant activity, boosting lipid buildup, and generating mitochondrial dysfunction, which leads to increased hepatocyte apoptosis and inflammation

Affected dogs may present with weakness, ataxia, disorientation, behavioural changes, collapse or seizures