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Nonetheless, this potential mechanism merits further investigation in the context of sleep disorders such as insomnia

Biomaterials 136, 1228

Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

Furthermore, Grx1-mediated deglutathionylation is crucial for efficient viral replication because Grx1 inhibition significantly reduces viral titres 28