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Their dysregulation whether by mutation, oxidative modification, or storage-related stress, induces a series of pathogenic outcomes

For instance, several post-transcriptional mechanisms induced additional variability in the spectrum of AR target gene transcripts

(Biochem Pharmacol 2018) documented a reduction of -35% in white adipose tissue, -40% in adipocyte volume, -5.1% in body weight and -30% in plasma cholesterol in just 11 days in obese mice (DIO), without any change in food intake

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