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Compared with -glucuronidase-based systems, -galactosidase-cleavable linkers are generally considered to favor intracellular activation, offering a release profile that may enable more controlled drug liberation with reduced reliance on extracellular bystander effects

A list of primer sequences for different genes used in the qPCR study is provided in Supplementary information (Table S1)

In South Korea it is 12 per 100,000 inhabitants [12], while it is higher in China with an estimated incidence of 24 per 100,000 [13]