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Acute toxicity in animal models is described as low for all three peptides individually, but coadministration data are sparse

The ERK1/2 Signaling Pathway The extracellular signal-regulated kinase (ERK1/2) pathway plays a crucial role in cellular proliferation, migration, and survival

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In wild-type mice, cagrilintide activates c-Fos-expressing neurons in the dorsal vagal complex (DVC), lateral parabrachial nucleus (LPBN), area postrema, and nucleus tractus solitarius brainstem regions critically involved in satiety signaling and suppression of food intake