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It shows an association of mutated NRAS with increased HGF-dependent activation of c-Met and with enhanced sensitivity to c-Met inhibition [81]

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Su desarrollo clnico avanz desde ensayos de fase 2 en monoterapia para obesidad y sobrepeso hacia su combinacin con semaglutida ( CagriSema ), que lleg a fase 3 dentro del programa REDEFINE, incluido el estudio REDEFINE-1 de 68 semanas