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Improved outcome after peripheral nerve injury in mice with increased levels of endogenous -3 polyunsaturated fatty acids

This elevation in NAD+ activates SIRT1, a master regulator of metabolic pathways that promotes fat oxidation, enhances mitochondrial function, and improves insulin sensitivity

The intrinsic factor-mediated pathway operates regardless of food presence, and the passive diffusion mechanism (responsible for absorbing about 1% of high doses) similarly functions independently of meals

B12 injections also support healing by fostering nerve and muscle regeneration, so they act as a restorative treatment as well as a form of pain relief