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Additionally, in preclinical research, a body weight ratio between the experimental model and humans may result in a relatively low clinically significant dose for intravenous delivery of nanomedicines (Park, 2019)

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Abbreviations A.A: Acetic acid DAI: Disease activity index DSS: Dextran sulphate sodium IBD: Inflammatory bowel disease JAK-STAT: Janus kinase/signal transducers and activators of transcription NF-B: Nuclear factor kappa B Nrf2: Nuclear factor erythroid 2related factor 2 NLRP3: Nucleotide-binding domain, leucine-richcontaining family, pyrin domaincontaining protein-3 NO: Nitric oxide synthase PPAR-: Peroxisome proliferator-activated receptor gamma TLR: Toll like receptor TNBS: 2, 4, 6-Trinitrobenzene sulfonic acid UC: Ulcerative colitis References Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JW, Abreu MT

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