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Topical preparations may use higher dilutions since they don't require injection-compatible volumes

Rare risks include copper sensitivity or toxicity with prolonged use which is why we monitor copper levels with periodic blood tests

Abu-Rumeileh S, Redaelli V, Baiardi S, Mackenzie G, Windl O, Ritchie DL, Didato G, Hernandez-Vara J, Rossi M, Capellari S, Imperiale D, Rizzone MG, Belotti A, Sorbi S, Rozemuller AJM, Cortelli P, Gelpi E, Will RG, Zerr I, Parchi P (2018) Sporadic fatal insomnia in Europe: phenotypic features and diagnostic challenges

However, the ongoing emergence of new variants, different immunization rates, supply chain issues, as well as the presence of smaller or larger outbreaks underlie the requirement for urgent treatments that can be rapidly deployed, says Martinez-Nunez and colleagues