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OMIN 151660) is a rare autosomal dominant disease characterized by regional loss of subcutaneous adipose tissue (limbs and trunk) that occurs progressively during peripubertal phase and is often associated with conspicuous insulin-resistance, diabetes, and other metabolic disturbances later in life ( FPLD2 is attributed to heterozygous missense mutations in the LMNA gene (MIM150330) on chromosome 1q2122 ( LMNA encodes lamins A and C, which are intermediate filament proteins consisting of a short N-terminal head, a central -helical rod domain, and a large C-terminal tail containing a globular immunoglobulin-like domain