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Ganetespib acts as a radiosensitizer in pancreatic ductal adenocarcinoma by disrupting HIF-1, STAT3, and AKT signaling and inducing G2-M cell cycle arrest, thereby impairing DNA damage repair during irradiation

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Protein kinase R-like endoplasmic reticulum kinase (PERK) activation triggers eukaryotic initiation factor 2 alpha (eIF2) phosphorylation specifically at serine 51, leading to selective mRNA translation despite global protein synthesis attenuation

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